MSA
RESEARCH

CURRENT TRIALS

BASIC SCIENCE RESEARCH

NEW PROMISING MSA DISEASE MODIFYING DRUG TRIAL

BHV-3241 is a first-in-class, brain-penetrant, irreversible myeloperoxidase (MPO) inhibitor that is being developed for the treatment of multiple system atrophy (MSA).

  • Has the potential to be developed in a number of disease indications associated with oxidative stress, inflammation, and neurodegeneration.
  • Potential to be a first-in-class and best-in-class agent.
  • Licensed from AstraZeneca in September 2018, where it was known as AZD3241.

MSA is a rare disease, affecting approximately 15,000 to 50,000 Americans. Some symptoms can be treated with medications but currently, there is no cure. Enter BioHaven, they are testing a new clinical drug that may slow MSA, multiple system atrophy (MSA). Check out MSA research study site:www.MSAresearchstudy.com

#msa #defeatmsa #kickmsa  #multiplesystematrophy #research

NEW NOVEL DRUG RESEARCH – PBT434

Happy to announce that PBT434 was granted orphan designation in USA & EU for Multiple System Atrophy; the maker Alterity, an Australian company plans to hold a clinical trial in Australia: https://alteritytherapeutics.com/…/european-commission-app…/

NEW PRE-CLINICAL MSA RELEVANT RESEARCH SUCCESS

CONGRATS TO DAVID MARMION ON HIS NEW MSA RESEARCH!

“There is an important role of the immune system to the pathophysiology of other synuclein-related diseases such as Parkinson’s disease. “

“These results suggest that T cell priming and infiltration into the CNS are key mechanisms of disease pathogenesis in MSA, and therapeutics targeting T cells may be disease modifying.”

https://link.springer.com/article/10.1007/s00401-020-02126-w

#defeatmsa #msaresearch #msashoe

Photo Below: David Marmion helps #kickmsa !

RESEARCHER BLOG

Dr. Amanda Woerman

Dr. Amanda Woerman

Dr. Wouter Peelaerts

Dr. Wouter Peelaerts

Member, Science and Medical Advisory Board

THE EXPERTS

A SPECIAL THANKS TO OUR MSA RESEARCHERS & HEALTH PROFESSIONALS AROUND THE WORLD!

Dr. Patrik Brundin

Van Andel Research Institute, Grand Rapids, Michigan, USA

Dr. Edwin George

Wayne State University, Detroit, Michigan, USA

Dr. Pravin Khemani

Swedish Neuroscience Institute, Seattle, Washington, USA

Dr. Janice Holton

University College London, London, United Kingdom

Dr. Horatio Kaufmann

Dysautonomia Center, New York University, New York, New York, USA

Dr. Wolfgang Singer

Mayo Clinic, Rochester, Minnesota, USA

Dr. Eduardo Benarroch

Mayo Clinic, Rochester, Minnesota, USA

Dr. Shilpa Chitnis

University of Texas Southwestern Medical Center, Dallas, Texas, USA

Dr. Walter J. Koroshetz

National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, Maryland, USA

Dr. John Q. Trojanowski

University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA

Dr. Paola Sandroni

Mayo Clinic Rochester, Minnesota

Dr. David Robertson

Vanderbilt Autonmic Dysfunction Center, Nashville, Tennessee, USA

Dr. Philip Low

Mayo Clinic, Rochester, Minnesota, USA

Dr. Praveen Dayalu

University of Michigan, Ann Arbor, Michigan, USA

Professor Gregor Wenning

Medical University, Innsbruck, Austria

Dr. Vik Khurana

Brigham and Women's Hospital, Harvard Medical School, Cambridge, Massachusetts, USA

Professor Eliezer Masliah

University of California, San Diego, California, USA

Dr. Matt Huentelman

T-Gen, Phoenix, Arizona, USA

Professor Glenda Halliday

Sydney Medical School, University of Sydney, Sydney, Australia

Dr. Aaron Ellenbogen

Michigan Institute for Neurological Disorders, Farmington Hills, Michigan, USA

Professor Werner Poewe

Innsbruck Medical University, Innsbruck, Austria

Dr. Un J. Kang

Irving Medical Center, Columbia University, New York, New York, USA

Dr. Charbel Moussa

Georgetown University, Washington, DC

Dr. Thomas Chelimsky

Medical College of Wisconsin, Wauwatosa, Wisconsin, USA

Dr. Ryan Walsh

Barrow Neurological Institute, Phoenix, Arizona, USA

Dr. Chuck Ide

Weestern Michigan University, Kalamazoo, Michigan, USA

Dr. Naill Quinn

University College London, London, United Kingdom

Dr. Roy Freeman

Beth Israel Deaconess, Boston, Massachusetts, USA

Dr. Michael Janitz

University of New South Wales, Sydney, Australia

Dr. Jeffrey Cummings

Cleveland Clinic, Lou Ruvo Center for Brain Health, Las Vegas, Nevada, USA

Dr. Joseph Jankovic

Baylor College of Medicine Medical Center, Houston, Texas, USA

Dr. Anthony Lang

Toronto Western Hospital Research Institute, Toronto, Canada

Dr. Jeffrey Kordower

Rush University, Chicago, Illinois, USA

Dr. Sid Gilman

Hope Clinic Ypsilanti, Michigan, USA

Dr. Glenn Cook

Director, Walter Reed National Military Medical Center, Clinical Neurocardiology Section, NINDS, NIH

Dr. Peter LeWitt

Henry Ford Health System, Detroit, Michigan, USA

Dr. Steven Vernino

University of Texas, Southwestern, Dallas, Texas, USA

Professor Florian Krismer

Medical University, Innsbruck, Austria

Dr. Wassilios Meissner

University Hospital Bordeaux, Bordeaux, France

Dr. Jeremy Schmahmann

Massachusetts General Hospital, Boston, Massachusetts, USA

Dr. Ronald Melki

Paris-Saclay Institute of Neuroscience, Saint-Aubin, France

Professor Shoji Tsuji

Medical Genome Center, University of Tokyo Hospital, Tokyo, Japan

Dr. Michael Schlossmacher

Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

Professor Gal Bitan

University of California - Los Angeles, Los Angeles, California, USA

Dr. Wendy R. Galpern

National Institute of Neurological Disorders and Stroke at the National Institutes of Health in Bethesda, Maryland, USA

Dr. Virginia Man-Yee Lee

University of Pennsylvania, Philadelphia, Pennsylvania, USA

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Any of these online pages published by Defeat MSA Down Under are for informational and support purposes only. The information presented in them should not be used for suggesting any diagnosis or understood as recommending any medicines, tests or treatments. Every visitor should consult with his/her doctor or other health care provider for any medical condition.

Furthermore, Defeat MSA Down Under has used all reasonable care to protect your privacy, ensure confidentiality and maintain a safe and secure online presence. For questions about the website or information contained therein, contact: msadownunder@gmail.com

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